July 24, 2012
"The brain needs stimulation to grow and develop, and we know the Romanian orphans are not getting that stimulation," Nelson said. 
Children who grow up in institutions instead of with families have major deficits in braindevelopment, a study of Romanian orphans has shown.
Researchers at Harvard University, the University of Maryland and Tulane University worked with Romanian authorities to place half the children with families that had been rigorously vetted to ensure they would provide good homes. Children living with their biological families have served as a control group.
The team has published almost 50 research papers since the project began, showing that the orphans who remained in institutions have significantly more behavioral and neurological deficits than those who went to families: At age 4 1/2, more than 40% had anxiety disorders and 4% had major depressive disorders. Many also exhibited signs ofautism such as "stereotypies," repetitive behaviors such as rocking and arm-flapping.
In the new study, the team scanned the brains of 74 of the Bucharest children, now ages 8 to 11, using magnetic resonance imaging.
What they found was striking: Brains of children who had remained in institutions had less white matter — the type of tissue that connects different regions of the brain — than orphans who were placed in foster care or children living with their own families.
Reductions in white matter have been found in numerous neurological and psychiatric conditions, including autism, schizophrenia and attention deficit hyperactivity disorder, or ADHD.
Study senior author Charles Nelson, a developmental neuroscientist at Children's Hospital Boston, said the white-matter changes were probably related to a difference that the scientists had noticed earlier in the project: Children in institutions had less electrical activity in their brains — specifically, a kind known as "alpha power" — than those who had gone to foster homes.
"If a normal kid is like a 100-watt light bulb, these kids were a 40-watt light bulb," Nelson said.
The observed brain differences seem to parallel some of the behavioral differences seen in the different groups of children — notably, higher rates of depression and anxiety disorders in kids who remained in institutions, Nelson said.
But the placements — the children went to families when they were 6 to 31 months old — did not wipe away all problems. Though the children with families were doing better than the children left in institutions, brains of both groups remained far from normal, Nelson said, with less gray matter than children who had been with families all along. Both groups also had significantly higher rates of ADHD and oppositional defiant disorder.
Perhaps, Nelson said, the children were placed in homes too late in life; deprivations they experienced before that time were profound. Children in the orphanages are often left in rooms by themselves for hours at a time with nothing to look at or play with.
Dr. Daniel Geschwind, an autism expert at UCLA who was not involved in the study, said the new report is "fundamental and foundational because it identifies clear structural abnormalities in the brains of these kids. Now we can ask 'Why?' What is it about these environments that alters brain structure and function?"
[The] kind of environment a child has from zero to 3 and 3 to 5 is fundamental to their future," he said.